Jobs

Postdoctoral Research Associate in Computational Biology – University of Bristol (CLOSED)

Computational tools for interactive and immersive multi-cellular design

Applications are invited for a Postdoctoral Research Associate (PDRA) position based in the School of Biological Sciences at the University of Bristol, UK. The successful candidate will join the Biocompute Lab (www.biocomputelab.org) and BrisSynBio (www.bristol.ac.uk/brissynbio), a BBSRC/EPSRC funded Synthetic Biology Research Centre. They will also work closely with the newly formed Virtual Reality for Synthetic Biology Laboratory at the University of Bristol.

The PDRA’s main role will be to lead the development of a new computational framework to enable interactive simulations of huge growing and evolving multi-cellular systems that can be observed and manipulated in virtual reality (VR). To make this possible, the agent-based simulations produced will exploit existing general-purpose physics engines to tap into the vast computational resources contained within modern computers, e.g. multi-core processors and highly-parallel graphics processing units (GPUs). This project will open completely new avenues for the rational engineering of multi-cellular biological systems. To explore the potential impact and establish this new research direction it is expected that the PDRAs research will extend to include: engagement with the public through outreach sessions in local schools, organization of an international agent-based modelling in bioengineering meeting (funding already secured), and to contribute to grant applications and develop fellowship proposals of their own to grow this research long-term.

Candidates should hold an undergraduate degree and PhD in a discipline relevant to high- performance computing (e.g., computer science, engineering, physics, mathematics, or a related subject), have a strong interest in biological systems and high-performance computing/simulation, and a proven track record of developing scalable and reusable code. They will also need to be highly motivated, collaborative, an excellent communicator, and have a desire to learn new skills and work within a diverse interdisciplinary team.

Online applications can be made at: http://goo.gl/1MD7xD

The deadline for applications is the 28th February 2018 and interviews are planned to take place late the following week. The position is scheduled to start on the 1st May 2018 (although earlier start dates may be possible) and will initially run for 14 months.

For further information or informal enquires please contact Dr Thomas Gorochowski (thomas.gorochowski@bristol.ac.uk)

 


Design and wet lab implementation of various biomolecular circuits/synthetic biology constructs and feedback control mechanisms in vivo for improving the robustness and performance of synthetic biology systems and engineered cells that need to operate in varying and uncertain environments. IMPERIAL COLLEGE (CLOSED)

Deadline for applications: 20 February 2018 (midnight GMT)

Brief description:

The Department of Bioengineering (Stan Group, http://www.bg.ic.ac.uk/research/g.stan/group,http://www.imperial.ac.uk/people/g.stan) at Imperial College London is seeking to appoint an excellent, highly motivated and dynamic Research Associate to join the new Imperial Centre for Synthetic Biology (IC-CSynB), on a fixed-term position to work on a novel and exciting synthetic biology project as part of the EPSRC Fellowship for Growth in Synthetic Biology of Dr Stan (http://gow.epsrc.ac.uk/NGBOViewGrant.aspx?GrantRef=EP/M002187/1) and includes collaboration with academic and industrial project partners.
 
The position will be based at the South Kensington Campus in the Stan Group, working closely with Dr Guy-Bart Stan, his research group and other members of IC-CSynB on a project focused on the design and wet lab implementation of various biomolecular circuits/synthetic biology constructs and feedback control mechanisms in vivo for improving the robustness and performance of synthetic biology systems and engineered cells that need to operate in varying and uncertain environments. These control mechanisms will address the robust performance of synthetic biology constructs at two levels: a) at the synthetic circuit level, to ensure orthogonal and precise dynamic control of heterologous gene expression and regulation, and b) at the host cell level, to alleviate or compensate for any burden due to competition for shared cellular resources or toxic related effects arising from the expression of heterologous genes.
 
We seek a highly motivated individual to fill this post, in possession of a PhD or equivalent in synthetic biology or a closely related area/discipline or equivalent research (e.g. microbiology, molecular biology, systems biology), with a focus on design of synthetic biology constructs, and experimental implementation, analysis and measurement of genetic and biomolecular circuits/systems or cellular engineering, and, ideally, with postdoctoral experience in a top synthetic biology lab.
 
The ideal candidate will have expertise in E. coli synthetic biology and microbial biology as well as background knowledge/previous exposure to mathematical modelling and numerical simulations of nonlinear dynamical models (deterministic and stochastic). The ideal candidate will be proficient in designing and cloning genes using next generation cloning methods (Gibson and Golden Gate) and in control engineering of cellular/biomolecular systems. Experience with FACS, genetic and/or metabolic engineering are essential. Expertise in computational modelling and scientific programming, e.g. using Matlab, Python or any other relevant programming language, are highly desirable. Ideal applicants should have a PhD (or equivalent) in synthetic biology, microbiology, molecular biology, or systems biology, or a closely related area/discipline, with a focus on design of synthetic biology constructs, and experimental implementation, analysis and measurement of genetic and biomolecular circuits/systems. Postdoctoral experience in a world-leading synthetic biology lab is highly desirable.

The post is funded by the UK Engineering and Physical Science Research Council (EPSRC).

For more details and to apply:https://www.imperial.ac.uk/jobs/description/ENG00185/research-assistantassociate